Betaine Anhydrous
What is Betaine Anhydrous?
Betaine Anhydrous, also known as trimethylglycine (TMG), is a naturally occurring compound derived from the amino acid glycine. It is found in foods like beets, spinach, and whole grains. In the context of fitness, Betaine Anhydrous has gained attention for its potential to enhance muscle performance and body composition.
Research suggests that betaine plays a role in methylation, a process essential for protein synthesis, liver function, and cardiovascular health. It is also known for its ability to support hydration at the cellular level, making it particularly useful in strength training and endurance sports (Healthline).
Benefits of Betaine Anhydrous in Fitness
Enhances Muscle Strength and Power
Several studies have shown that Betaine Anhydrous supplementation can improve muscle strength and power output, particularly in resistance-trained athletes. It has been linked to increased work capacity, greater force production, and improved endurance during high-intensity training sessions (NCBI).
Supports Muscle Growth and Fat Loss
Betaine supplementation has been shown to positively influence lean muscle mass and body composition. Research suggests that daily betaine intake may contribute to muscle hypertrophy while simultaneously reducing fat mass (NCBI).
Aids in Recovery and Reduces Fatigue
By supporting hydration at the cellular level, betaine helps maintain fluid balance in muscle cells, reducing the risk of dehydration-induced fatigue. Additionally, betaine may lower homocysteine levels, a factor linked to muscle soreness and delayed recovery (NCBI).
Dosage and Supplementation
For fitness and performance enhancement, the recommended dosage of Betaine Anhydrous typically ranges from 2.5 to 6 grams per day. It is commonly included in pre-workout supplements due to its performance-boosting properties.
For body composition benefits: 2.5g daily for at least 6 weeks for improved lean mass (Health.com).
For strength and power: 2.5g – 6g per day, taken 30–60 minutes before training.
Side Effects and Safety
Betaine Anhydrous is generally well-tolerated, but some individuals may experience mild side effects, including:
- Gastrointestinal discomfort, such as nausea, bloating, or diarrhea (WebMD).
 - Body odor (a mild fish-like smell), which can occur in rare cases due to increased methylation (Cleveland Clinic).
 
People with pre-existing conditions such as kidney disease or cardiovascular issues should consult a healthcare professional before supplementing with betaine (Mount Sinai).
Dietary Sources
Betaine is naturally present in various foods, including:
- Beets – One of the richest natural sources.
 - Spinach – Contains high levels of betaine.
 - Whole Grains – Wheat bran, quinoa, and rye are good sources.
 
While diet provides some betaine, supplementation is often required to reach the doses associated with performance benefits (Wikipedia).
Combining Betaine Anhydrous with Other Supplements
Betaine Anhydrous pairs well with other fitness and muscle-building supplements, such as:
Protein Supplements – Supports muscle growth and recovery when combined with adequate protein intake.
Creatine – May have a synergistic effect on muscle strength and power (GetShifted).
FAQs about Betaine Anhydrous
While betaine is primarily used for muscle growth and performance, studies suggest it may support fat loss by improving body composition (Healthline).
Yes, betaine is generally safe for long-term use within recommended doses. However, individuals with pre-existing conditions should consult a doctor before supplementing (Apollo Hospitals).
Betaine can be taken with or without food, but some users find that consuming it with a meal reduces the risk of mild stomach discomfort.
Betaine is often stacked with creatine and protein without known adverse effects. However, it’s always best to monitor individual responses.
Individuals with kidney disease, heart conditions, or elevated cholesterol levels should use betaine with caution and seek medical advice before supplementation (Apollo Hospitals).